TY - GEN
T1 - Toward implantable glucometer
T2 - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
AU - Ghafar-Zadeh, Ebrahim
AU - Gholamzadeh, Bahareh
AU - Awwad, Falah
AU - Sawan, Mohamad
PY - 2013
Y1 - 2013
N2 - We put forward an implantable glucometers using a biologically inspired sensor (BioS) method. In this method, engineered glucokinase (GLK) molecules are used as nanoscale glucometers. Herein, we describe two computational and experimental models of GLKs exposed to glucose molecules. The simulation results significantly show the detection of GLK binding to glucose. We thereafter reveal the applicability of this technique for continuous glucose monitoring by demonstrating and discussing the experimental results. Based on these results the glucose measurement with various glucose concentrations (0.5 mM, 1 mM and 2.5 mM) were precisely performed and repeated for more than 4 weeks. These results prove the advantage of proposed BioS method for continuous measurement of glucose.
AB - We put forward an implantable glucometers using a biologically inspired sensor (BioS) method. In this method, engineered glucokinase (GLK) molecules are used as nanoscale glucometers. Herein, we describe two computational and experimental models of GLKs exposed to glucose molecules. The simulation results significantly show the detection of GLK binding to glucose. We thereafter reveal the applicability of this technique for continuous glucose monitoring by demonstrating and discussing the experimental results. Based on these results the glucose measurement with various glucose concentrations (0.5 mM, 1 mM and 2.5 mM) were precisely performed and repeated for more than 4 weeks. These results prove the advantage of proposed BioS method for continuous measurement of glucose.
UR - http://www.scopus.com/inward/record.url?scp=84886532365&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886532365&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2013.6610834
DO - 10.1109/EMBC.2013.6610834
M3 - Conference contribution
C2 - 24111021
AN - SCOPUS:84886532365
SN - 9781457702167
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 5658
EP - 5661
BT - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Y2 - 3 July 2013 through 7 July 2013
ER -