Towards a computational reconstruction of the electrodynamics of premature and full term human labour

O. Aslanidi; J. Atia; A. P. Benson; H. A. van den Berg; A. M. Blanks; C. Choi; S. H. Gilbert; I. Goryanin; B. R. Hayes-Gill; A. V. Holden; P. Li; J. E. Norman; A. Shmygol; N. A.B. Simpson; M. J. Taggart; W. C. Tong; H. Zhang

doi:10.1016/j.pbiomolbio.2011.07.004

Towards a computational reconstruction of the electrodynamics of premature and full term human labour

O. Aslanidi, J. Atia, A. P. Benson, H. A. van den Berg, A. M. Blanks, C. Choi, S. H. Gilbert, I. Goryanin, B. R. Hayes-Gill, A. V. Holden, P. Li, J. E. Norman, A. Shmygol, N. A.B. Simpson, M. J. Taggart, W. C. Tong, H. Zhang

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

We apply virtual tissue engineering to the full term human uterus with a view to reconstruction of the spatiotemporal patterns of electrical activity of the myometrium that control mechanical activity via intracellular calcium. The three-dimensional geometry of the gravid uterus has been reconstructed from segmented in vivo magnetic resonance imaging as well as ex vivo diffusion tensor magnetic resonance imaging to resolve fine scale tissue architecture. A late-pregnancy uterine smooth muscle cell model is constructed and bursting analysed using continuation algorithms. These cell models are incorporated into partial differential equation models for tissue synchronisation and propagation. The ultimate objective is to develop a quantitative and predictive understanding of the mechanisms that initiate and regulate labour.

Original language	English
Pages (from-to)	183-192
Number of pages	10
Journal	Progress in Biophysics and Molecular Biology
Volume	107
Issue number	1
DOIs	https://doi.org/10.1016/j.pbiomolbio.2011.07.004
Publication status	Published - Oct 2011
Externally published	Yes

Keywords

Electrophysiology
Mathematical modelling
Physiome
Smooth muscle
Uterine

ASJC Scopus subject areas

Biophysics
Molecular Biology

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10.1016/j.pbiomolbio.2011.07.004

Cite this

Aslanidi, O., Atia, J., Benson, A. P., van den Berg, H. A., Blanks, A. M., Choi, C., Gilbert, S. H., Goryanin, I., Hayes-Gill, B. R., Holden, A. V., Li, P., Norman, J. E., Shmygol, A., Simpson, N. A. B., Taggart, M. J., Tong, W. C., & Zhang, H. (2011). Towards a computational reconstruction of the electrodynamics of premature and full term human labour. Progress in Biophysics and Molecular Biology, 107(1), 183-192. https://doi.org/10.1016/j.pbiomolbio.2011.07.004

Aslanidi, O, Atia, J, Benson, AP, van den Berg, HA, Blanks, AM, Choi, C, Gilbert, SH, Goryanin, I, Hayes-Gill, BR, Holden, AV, Li, P, Norman, JE, Shmygol, A, Simpson, NAB, Taggart, MJ, Tong, WC & Zhang, H 2011, 'Towards a computational reconstruction of the electrodynamics of premature and full term human labour', Progress in Biophysics and Molecular Biology, vol. 107, no. 1, pp. 183-192. https://doi.org/10.1016/j.pbiomolbio.2011.07.004

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abstract = "We apply virtual tissue engineering to the full term human uterus with a view to reconstruction of the spatiotemporal patterns of electrical activity of the myometrium that control mechanical activity via intracellular calcium. The three-dimensional geometry of the gravid uterus has been reconstructed from segmented in vivo magnetic resonance imaging as well as ex vivo diffusion tensor magnetic resonance imaging to resolve fine scale tissue architecture. A late-pregnancy uterine smooth muscle cell model is constructed and bursting analysed using continuation algorithms. These cell models are incorporated into partial differential equation models for tissue synchronisation and propagation. The ultimate objective is to develop a quantitative and predictive understanding of the mechanisms that initiate and regulate labour.",

keywords = "Electrophysiology, Mathematical modelling, Physiome, Smooth muscle, Uterine",

author = "O. Aslanidi and J. Atia and Benson, {A. P.} and {van den Berg}, {H. A.} and Blanks, {A. M.} and C. Choi and Gilbert, {S. H.} and I. Goryanin and Hayes-Gill, {B. R.} and Holden, {A. V.} and P. Li and Norman, {J. E.} and A. Shmygol and Simpson, {N. A.B.} and Taggart, {M. J.} and Tong, {W. C.} and H. Zhang",

year = "2011",

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doi = "10.1016/j.pbiomolbio.2011.07.004",

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AU - Blanks, A. M.

AU - Choi, C.

AU - Gilbert, S. H.

AU - Goryanin, I.

AU - Hayes-Gill, B. R.

AU - Holden, A. V.

AU - Li, P.

AU - Norman, J. E.

AU - Shmygol, A.

AU - Simpson, N. A.B.

AU - Taggart, M. J.

AU - Tong, W. C.

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KW - Electrophysiology

KW - Mathematical modelling

KW - Physiome

KW - Smooth muscle

KW - Uterine

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Towards a computational reconstruction of the electrodynamics of premature and full term human labour

Abstract

Keywords

ASJC Scopus subject areas

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