TY - JOUR
T1 - Toxicokinetics of aflatoxin in pregnant mice
AU - Bastaki, Salim A.
AU - Osman, Nawal
AU - Kochiyil, Jose
AU - Shafiullah, Mohamed
AU - Padmanabhan, Rengasamy
AU - Abdulrazzaq, Yousef M.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research and/or authorship of this article: Research Affairs at the UAE University under a contract no. 17-7-11/02.
PY - 2010
Y1 - 2010
N2 - Our objective was to study the toxicokinetics of aflatoxin (AF) in pregnant mice. Aflatoxin B1 (AFB1) was administered intraperitoneally (IP) to groups of pregnant mice in single doses of 20 mg/kg on gestation day (GD) 13 and orally at the same gestational age. Controls received (IP and oral) a proportionate volume of solvent only. Maternal blood was collected at 15, 30, 45, 60, 90, 120, and 150 minutes posttreatment. Their AFB1 contents were determined. Aflatoxin B1 concentrations following maternal exposure to AFB1 were highly correlated with time after exposure. The serum concentrations were predictable and the highest serum levels were seen immediately at 15 minutes in mice given AFs IP and at 30 minutes in those given it orally. The absorption was 5.0 μg/min and elimination was 3.0 μg/min. The toxicokinetics of AFB1 have been delineated. Aflatoxins are easily and rapidly absorbed both from the gastrointestinal tract (GI) tract and through the peritoneum.
AB - Our objective was to study the toxicokinetics of aflatoxin (AF) in pregnant mice. Aflatoxin B1 (AFB1) was administered intraperitoneally (IP) to groups of pregnant mice in single doses of 20 mg/kg on gestation day (GD) 13 and orally at the same gestational age. Controls received (IP and oral) a proportionate volume of solvent only. Maternal blood was collected at 15, 30, 45, 60, 90, 120, and 150 minutes posttreatment. Their AFB1 contents were determined. Aflatoxin B1 concentrations following maternal exposure to AFB1 were highly correlated with time after exposure. The serum concentrations were predictable and the highest serum levels were seen immediately at 15 minutes in mice given AFs IP and at 30 minutes in those given it orally. The absorption was 5.0 μg/min and elimination was 3.0 μg/min. The toxicokinetics of AFB1 have been delineated. Aflatoxins are easily and rapidly absorbed both from the gastrointestinal tract (GI) tract and through the peritoneum.
KW - absorption
KW - aflatoxin
KW - toxicokinetics
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U2 - 10.1177/1091581810369565
DO - 10.1177/1091581810369565
M3 - Article
C2 - 20484621
AN - SCOPUS:77956289844
SN - 1091-5818
VL - 29
SP - 425
EP - 431
JO - International Journal of Toxicology
JF - International Journal of Toxicology
IS - 4
ER -