Trefoil factor family (TFF) peptides and cancer progression

Shahin Emami, Sylvie Rodrigues, Christelle M. Rodrigue, Nathalie Le Floch, Christine Rivat, Samir Attoub, Erik Bruyneel, Christian Gespach

Research output: Contribution to journalReview articlepeer-review

110 Citations (Scopus)

Abstract

TFF peptides are involved in mucosal maintenance and repair through motogenic and antiapoptotic activities. These peptides are overexpressed during inflammatory processes and cancer progression. They also function as scatter factors, proinvasive and angiogenic agents. Such a divergence is related to the pathophysiological state of tissues submitted to persistent aggressive situations during digestive processes in the normal gastrointestinal tract, inflammatory and neoplastic diseases. In agreement with this model, TFF peptides are connected with multiple oncogenic pathways. As a consequence, the TFF signaling pathways may serve as potential targets in the control of chronic inflammation and progression of human solid tumors.

Original languageEnglish
Pages (from-to)885-898
Number of pages14
JournalPeptides
Volume25
Issue number5
DOIs
Publication statusPublished - May 2004
Externally publishedYes

Keywords

  • Angiogenesis
  • Apoptosis
  • COX-1
  • COX-2
  • EGF-R
  • Invasion
  • PI3′-kinase
  • PLC
  • RhoAGTPase
  • Scattering
  • TXA-2-R
  • src

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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