Trefoil factor family (TFF) peptides and cancer progression

Shahin Emami; Sylvie Rodrigues; Christelle M. Rodrigue; Nathalie Le Floch; Christine Rivat; Samir Attoub; Erik Bruyneel; Christian Gespach

doi:10.1016/j.peptides.2003.10.019

Trefoil factor family (TFF) peptides and cancer progression

Shahin Emami, Sylvie Rodrigues, Christelle M. Rodrigue, Nathalie Le Floch, Christine Rivat, Samir Attoub, Erik Bruyneel, Christian Gespach

Research output: Contribution to journal › Review article › peer-review

107 Citations (Scopus)

Abstract

TFF peptides are involved in mucosal maintenance and repair through motogenic and antiapoptotic activities. These peptides are overexpressed during inflammatory processes and cancer progression. They also function as scatter factors, proinvasive and angiogenic agents. Such a divergence is related to the pathophysiological state of tissues submitted to persistent aggressive situations during digestive processes in the normal gastrointestinal tract, inflammatory and neoplastic diseases. In agreement with this model, TFF peptides are connected with multiple oncogenic pathways. As a consequence, the TFF signaling pathways may serve as potential targets in the control of chronic inflammation and progression of human solid tumors.

Original language	English
Pages (from-to)	885-898
Number of pages	14
Journal	Peptides
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.peptides.2003.10.019
Publication status	Published - May 2004
Externally published	Yes

Keywords

Angiogenesis
Apoptosis
COX-1
COX-2
EGF-R
Invasion
PI3′-kinase
PLC
RhoAGTPase
Scattering
TXA-2-R
src

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

Access to Document

10.1016/j.peptides.2003.10.019

Cite this

@article{e0f4cdb487514039b67fe6a8cb7daecc,

title = "Trefoil factor family (TFF) peptides and cancer progression",

abstract = "TFF peptides are involved in mucosal maintenance and repair through motogenic and antiapoptotic activities. These peptides are overexpressed during inflammatory processes and cancer progression. They also function as scatter factors, proinvasive and angiogenic agents. Such a divergence is related to the pathophysiological state of tissues submitted to persistent aggressive situations during digestive processes in the normal gastrointestinal tract, inflammatory and neoplastic diseases. In agreement with this model, TFF peptides are connected with multiple oncogenic pathways. As a consequence, the TFF signaling pathways may serve as potential targets in the control of chronic inflammation and progression of human solid tumors.",

keywords = "Angiogenesis, Apoptosis, COX-1, COX-2, EGF-R, Invasion, PI3′-kinase, PLC, RhoAGTPase, Scattering, TXA-2-R, src",

author = "Shahin Emami and Sylvie Rodrigues and Rodrigue, {Christelle M.} and {Le Floch}, Nathalie and Christine Rivat and Samir Attoub and Erik Bruyneel and Christian Gespach",

note = "Funding Information: Supported by INSERM, Paris VI University, Research Grants, Ph.D. and post-doctoral fundings from: Aventis, the French Associations for Cancer Research (ARC, La Ligue contre le Cancer), AstraZeneca, IPSEN, GEFLUC, the French Ministry of Scientific Research, the Conseil G{\'e}n{\'e}ral de la Guadeloupe (FWI), and La Fondation pour la Recherche M{\'e}dicale.",

year = "2004",

month = may,

doi = "10.1016/j.peptides.2003.10.019",

language = "English",

volume = "25",

pages = "885--898",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Trefoil factor family (TFF) peptides and cancer progression

AU - Emami, Shahin

AU - Rodrigues, Sylvie

AU - Rodrigue, Christelle M.

AU - Le Floch, Nathalie

AU - Rivat, Christine

AU - Attoub, Samir

AU - Bruyneel, Erik

AU - Gespach, Christian

N1 - Funding Information: Supported by INSERM, Paris VI University, Research Grants, Ph.D. and post-doctoral fundings from: Aventis, the French Associations for Cancer Research (ARC, La Ligue contre le Cancer), AstraZeneca, IPSEN, GEFLUC, the French Ministry of Scientific Research, the Conseil Général de la Guadeloupe (FWI), and La Fondation pour la Recherche Médicale.

PY - 2004/5

Y1 - 2004/5

N2 - TFF peptides are involved in mucosal maintenance and repair through motogenic and antiapoptotic activities. These peptides are overexpressed during inflammatory processes and cancer progression. They also function as scatter factors, proinvasive and angiogenic agents. Such a divergence is related to the pathophysiological state of tissues submitted to persistent aggressive situations during digestive processes in the normal gastrointestinal tract, inflammatory and neoplastic diseases. In agreement with this model, TFF peptides are connected with multiple oncogenic pathways. As a consequence, the TFF signaling pathways may serve as potential targets in the control of chronic inflammation and progression of human solid tumors.

AB - TFF peptides are involved in mucosal maintenance and repair through motogenic and antiapoptotic activities. These peptides are overexpressed during inflammatory processes and cancer progression. They also function as scatter factors, proinvasive and angiogenic agents. Such a divergence is related to the pathophysiological state of tissues submitted to persistent aggressive situations during digestive processes in the normal gastrointestinal tract, inflammatory and neoplastic diseases. In agreement with this model, TFF peptides are connected with multiple oncogenic pathways. As a consequence, the TFF signaling pathways may serve as potential targets in the control of chronic inflammation and progression of human solid tumors.

KW - Angiogenesis

KW - Apoptosis

KW - COX-1

KW - COX-2

KW - EGF-R

KW - Invasion

KW - PI3′-kinase

KW - PLC

KW - RhoAGTPase

KW - Scattering

KW - TXA-2-R

KW - src

UR - http://www.scopus.com/inward/record.url?scp=2642522719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2642522719&partnerID=8YFLogxK

U2 - 10.1016/j.peptides.2003.10.019

DO - 10.1016/j.peptides.2003.10.019

M3 - Review article

C2 - 15177885

AN - SCOPUS:2642522719

SN - 0196-9781

VL - 25

SP - 885

EP - 898

JO - Peptides

JF - Peptides

IS - 5

ER -

Trefoil factor family (TFF) peptides and cancer progression

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this