Two novel related peptides, neuropeptide Y (NPY) and peptide YY (PYY) inhibit the contraction of the electrically stimulated mouse vas deferens

JM Allen; TE Adrian; K. Tatemoto; JM Polak; J. Hughes; SR Bloom

doi:10.1016/0143-4179(82)90001-4

Two novel related peptides, neuropeptide Y (NPY) and peptide YY (PYY) inhibit the contraction of the electrically stimulated mouse vas deferens

JM Allen, TE Adrian, K. Tatemoto, JM Polak, J. Hughes, SR Bloom

Research output: Contribution to journal › Article › peer-review

151 Citations (Scopus)

Abstract

The action of two related peptides, neuropeptide Y (NPY) and peptide YY (PYY) on the mouse vas deferens was investigated. Both peptides potently inhibited in a dose dependent manner, muscle contractions evoked by electrical field stimulation of the intramural neurons but did not alter noradrenaline evoked contractions. They were also found to inhibit the potentiation of the twitch elicited by neurotensin and substance P. NPY and PYY were equipotent in the bioassay. This data suggests the possibility that NPY acts as a neuromodulator of noradrenaline release at a presynaptic level in the mouse vas deferens.

Original language	English
Pages (from-to)	71-77
Number of pages	7
Journal	Neuropeptides
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/0143-4179(82)90001-4
Publication status	Published - Dec 1982
Externally published	Yes

ASJC Scopus subject areas

Endocrinology
Neurology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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10.1016/0143-4179(82)90001-4

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abstract = "The action of two related peptides, neuropeptide Y (NPY) and peptide YY (PYY) on the mouse vas deferens was investigated. Both peptides potently inhibited in a dose dependent manner, muscle contractions evoked by electrical field stimulation of the intramural neurons but did not alter noradrenaline evoked contractions. They were also found to inhibit the potentiation of the twitch elicited by neurotensin and substance P. NPY and PYY were equipotent in the bioassay. This data suggests the possibility that NPY acts as a neuromodulator of noradrenaline release at a presynaptic level in the mouse vas deferens.",

author = "JM Allen and TE Adrian and K. Tatemoto and JM Polak and J. Hughes and SR Bloom",

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AU - Allen, JM

AU - Adrian, TE

AU - Tatemoto, K.

AU - Polak, JM

AU - Hughes, J.

AU - Bloom, SR

PY - 1982/12

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AB - The action of two related peptides, neuropeptide Y (NPY) and peptide YY (PYY) on the mouse vas deferens was investigated. Both peptides potently inhibited in a dose dependent manner, muscle contractions evoked by electrical field stimulation of the intramural neurons but did not alter noradrenaline evoked contractions. They were also found to inhibit the potentiation of the twitch elicited by neurotensin and substance P. NPY and PYY were equipotent in the bioassay. This data suggests the possibility that NPY acts as a neuromodulator of noradrenaline release at a presynaptic level in the mouse vas deferens.

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Two novel related peptides, neuropeptide Y (NPY) and peptide YY (PYY) inhibit the contraction of the electrically stimulated mouse vas deferens

Abstract

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