UiO-66-NH2as an effective solid support for quinazoline derivatives for antibacterial agents against Gram-negative bacteria

Shaikha S. Al Neyadi, Afra G. Al Blooshi, Ha L. Nguyen, Mohamed A. Alnaqbi

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Nanomaterials have been widely used as a class of antibacterial drugs. However, the bottlenecks of this class of materials are their significant aggregation and accumulation, as well as toxicity resulting from excessive metal leaching. Metal-organic frameworks (MOFs) have inspired researchers owing to their distinct characteristics of robust architecture and tunable pore structures, which may help overcome the above challenges. We, herein, synthesize UiO-66-NH2 and use it as a solid support for loading quinazoline derivatives that are specifically designed and active against Gram-negative bacteria. The quinazoline derivatives were adsorbed on UiO-66-NH2 nanoparticles to form new UiO-66-NH2-quinazoline formulations which have a large inhibitory zone against Gram-negative bacteria, compared to that of free quinazoline compounds. This work has the potential for increasing antibacterial activity while also broadening the antibacterial range, and thus opens a pathway for new medical applications using MOFs.

Original languageEnglish
Pages (from-to)20386-20395
Number of pages10
JournalNew Journal of Chemistry
Volume45
Issue number43
DOIs
Publication statusPublished - Nov 21 2021

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Materials Chemistry

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