TY - JOUR
T1 - UiO-66-NH2as an effective solid support for quinazoline derivatives for antibacterial agents against Gram-negative bacteria
AU - Al Neyadi, Shaikha S.
AU - Al Blooshi, Afra G.
AU - Nguyen, Ha L.
AU - Alnaqbi, Mohamed A.
N1 - Funding Information:
We acknowledge Mr Bassam Hindawi, Ms Shaikha S. Alketbi, and Ms Ruba Al Ajei (UAE University) for their effort in measuring N2 isotherms and FT-IR spectroscopy. We acknowledge the financial support from the United Arab Emirates University Program for Advanced Research (UPAR Fund No. 31S316 for Grant G00002654).
Publisher Copyright:
© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
PY - 2021/11/21
Y1 - 2021/11/21
N2 - Nanomaterials have been widely used as a class of antibacterial drugs. However, the bottlenecks of this class of materials are their significant aggregation and accumulation, as well as toxicity resulting from excessive metal leaching. Metal-organic frameworks (MOFs) have inspired researchers owing to their distinct characteristics of robust architecture and tunable pore structures, which may help overcome the above challenges. We, herein, synthesize UiO-66-NH2 and use it as a solid support for loading quinazoline derivatives that are specifically designed and active against Gram-negative bacteria. The quinazoline derivatives were adsorbed on UiO-66-NH2 nanoparticles to form new UiO-66-NH2-quinazoline formulations which have a large inhibitory zone against Gram-negative bacteria, compared to that of free quinazoline compounds. This work has the potential for increasing antibacterial activity while also broadening the antibacterial range, and thus opens a pathway for new medical applications using MOFs.
AB - Nanomaterials have been widely used as a class of antibacterial drugs. However, the bottlenecks of this class of materials are their significant aggregation and accumulation, as well as toxicity resulting from excessive metal leaching. Metal-organic frameworks (MOFs) have inspired researchers owing to their distinct characteristics of robust architecture and tunable pore structures, which may help overcome the above challenges. We, herein, synthesize UiO-66-NH2 and use it as a solid support for loading quinazoline derivatives that are specifically designed and active against Gram-negative bacteria. The quinazoline derivatives were adsorbed on UiO-66-NH2 nanoparticles to form new UiO-66-NH2-quinazoline formulations which have a large inhibitory zone against Gram-negative bacteria, compared to that of free quinazoline compounds. This work has the potential for increasing antibacterial activity while also broadening the antibacterial range, and thus opens a pathway for new medical applications using MOFs.
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U2 - 10.1039/d1nj03749h
DO - 10.1039/d1nj03749h
M3 - Article
AN - SCOPUS:85120044522
SN - 1144-0546
VL - 45
SP - 20386
EP - 20395
JO - New Journal of Chemistry
JF - New Journal of Chemistry
IS - 43
ER -