Unraveling Lifelong Brain Morphometric Dynamics: A Protocol for Systematic Review and Meta-Analysis in Healthy Neurodevelopment and Ageing

Yauhen Statsenko, Tetiana Habuza, Darya Smetanina, Gillian Lylian Simiyu, Sarah Meribout, Fransina Christina King, Juri G. Gelovani, Karuna M. Das, Klaus N.V. Gorkom, Kornelia Zaręba, Taleb M. Almansoori, Miklós Szólics, Fatima Ismail, Milos Ljubisavljevic

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A high incidence and prevalence of neurodegenerative diseases and neurodevelopmental disorders justify the necessity of well-defined criteria for diagnosing these pathologies from brain imaging findings. No easy-to-apply quantitative markers of abnormal brain development and ageing are available. We aim to find the characteristic features of non-pathological development and degeneration in distinct brain structures and to work out a precise descriptive model of brain morphometry in age groups. We will use four biomedical databases to acquire original peer-reviewed publications on brain structural changes occurring throughout the human life-span. Selected publications will be uploaded to Covidence systematic review software for automatic deduplication and blinded screening. Afterwards, we will manually review the titles, abstracts, and full texts to identify the papers matching eligibility criteria. The relevant data will be extracted to a ‘Summary of findings’ table. This will allow us to calculate the annual rate of change in the volume or thickness of brain structures and to model the lifelong dynamics in the morphometry data. Finally, we will adjust the loss of weight/thickness in specific brain areas to the total intracranial volume. The systematic review will synthesise knowledge on structural brain change across the life-span.

Original languageEnglish
Article number1999
JournalBiomedicines
Volume11
Issue number7
DOIs
Publication statusPublished - Jul 2023

Keywords

  • ageing
  • atrophy
  • brain
  • brain diseases
  • cognition
  • meta-analysis
  • nerve degeneration
  • neurodevelopmental disorders
  • neuroimaging
  • regression analysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Biochemistry,Genetics and Molecular Biology

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