Unraveling the potential nutritional benefits of fermented date syrup waste: Untargeted metabolomics and carbohydrate metabolites of in vitro digested fraction

Nadia S. Alkalbani; Muneeba Zubair Alam; Anas Al-Nabulsi; Tareq M. Osaili; Reyad R. Obaid; Shao Quan Liu; Afaf Kamal-Eldin; Mutamed Ayyash

doi:10.1016/j.foodchem.2024.138483

Unraveling the potential nutritional benefits of fermented date syrup waste: Untargeted metabolomics and carbohydrate metabolites of in vitro digested fraction

Nadia S. Alkalbani, Muneeba Zubair Alam, Anas Al-Nabulsi, Tareq M. Osaili, Reyad R. Obaid, Shao Quan Liu, Afaf Kamal-Eldin, Mutamed Ayyash

Research output: Contribution to journal › Article › peer-review

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Abstract

Valorization of fruit by-products is a crucial area of research for the development of innovative bio-based products. This study investigated the physicochemical properties and health-promoting benefits of date syrup waste, both fermented by Pichia cecembensis or Pichia kudriavzevii (FDSW), and unfermented (CDSW). Metabolomics profiles of these samples were identified post in vitro digestion. FDSW exhibited 42 volatile compounds, including 9 new ones, and contained (-)-epicatechin, tyrosol, and gallic acid. Bioaccessible fractions of FDSW demonstrated substantial α-amylase inhibition, with percentages of 40.7 % and 53.9 %, respectively. FDSW displayed superior cytotoxicity against Caco2 and MCF-7 cancer cell lines, with an average of ∼75 % and 56 %, respectively. Untargeted metabolomics analysis revealed an increase in secondary metabolites, totaling 27 metabolites. LC-QTOF analysis of bioaccessible carbohydrate metabolites in FDSW identified two phytochemical groups, alkaloids, and terpenoids. This study underscores the potential of FDSW for producing value-added bio-based products with desirable characteristics and health benefits.

Original language	English
Article number	138483
Journal	Food Chemistry
Volume	442
DOIs	https://doi.org/10.1016/j.foodchem.2024.138483
Publication status	Published - Jun 1 2024

Keywords

ACE-inhibition
Antidiabetics
Antioxidant
Cytotoxicity
Fruit waste
Functional compounds
Phenolic compounds
UPLC-QTOF

ASJC Scopus subject areas

Analytical Chemistry
Food Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.foodchem.2024.138483

Cite this

Alkalbani, N. S., Alam, M. Z., Al-Nabulsi, A., Osaili, T. M., Obaid, R. R., Liu, S. Q., Kamal-Eldin, A., & Ayyash, M. (2024). Unraveling the potential nutritional benefits of fermented date syrup waste: Untargeted metabolomics and carbohydrate metabolites of in vitro digested fraction. Food Chemistry, 442, Article 138483. https://doi.org/10.1016/j.foodchem.2024.138483

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title = "Unraveling the potential nutritional benefits of fermented date syrup waste: Untargeted metabolomics and carbohydrate metabolites of in vitro digested fraction",

abstract = "Valorization of fruit by-products is a crucial area of research for the development of innovative bio-based products. This study investigated the physicochemical properties and health-promoting benefits of date syrup waste, both fermented by Pichia cecembensis or Pichia kudriavzevii (FDSW), and unfermented (CDSW). Metabolomics profiles of these samples were identified post in vitro digestion. FDSW exhibited 42 volatile compounds, including 9 new ones, and contained (-)-epicatechin, tyrosol, and gallic acid. Bioaccessible fractions of FDSW demonstrated substantial α-amylase inhibition, with percentages of 40.7 % and 53.9 %, respectively. FDSW displayed superior cytotoxicity against Caco2 and MCF-7 cancer cell lines, with an average of ∼75 % and 56 %, respectively. Untargeted metabolomics analysis revealed an increase in secondary metabolites, totaling 27 metabolites. LC-QTOF analysis of bioaccessible carbohydrate metabolites in FDSW identified two phytochemical groups, alkaloids, and terpenoids. This study underscores the potential of FDSW for producing value-added bio-based products with desirable characteristics and health benefits.",

keywords = "ACE-inhibition, Antidiabetics, Antioxidant, Cytotoxicity, Fruit waste, Functional compounds, Phenolic compounds, UPLC-QTOF",

author = "Alkalbani, {Nadia S.} and Alam, {Muneeba Zubair} and Anas Al-Nabulsi and Osaili, {Tareq M.} and Obaid, {Reyad R.} and Liu, {Shao Quan} and Afaf Kamal-Eldin and Mutamed Ayyash",

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year = "2024",

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doi = "10.1016/j.foodchem.2024.138483",

language = "English",

volume = "442",

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T1 - Unraveling the potential nutritional benefits of fermented date syrup waste

T2 - Untargeted metabolomics and carbohydrate metabolites of in vitro digested fraction

AU - Alkalbani, Nadia S.

AU - Alam, Muneeba Zubair

AU - Al-Nabulsi, Anas

AU - Osaili, Tareq M.

AU - Obaid, Reyad R.

AU - Liu, Shao Quan

AU - Kamal-Eldin, Afaf

AU - Ayyash, Mutamed

PY - 2024/6/1

Y1 - 2024/6/1

N2 - Valorization of fruit by-products is a crucial area of research for the development of innovative bio-based products. This study investigated the physicochemical properties and health-promoting benefits of date syrup waste, both fermented by Pichia cecembensis or Pichia kudriavzevii (FDSW), and unfermented (CDSW). Metabolomics profiles of these samples were identified post in vitro digestion. FDSW exhibited 42 volatile compounds, including 9 new ones, and contained (-)-epicatechin, tyrosol, and gallic acid. Bioaccessible fractions of FDSW demonstrated substantial α-amylase inhibition, with percentages of 40.7 % and 53.9 %, respectively. FDSW displayed superior cytotoxicity against Caco2 and MCF-7 cancer cell lines, with an average of ∼75 % and 56 %, respectively. Untargeted metabolomics analysis revealed an increase in secondary metabolites, totaling 27 metabolites. LC-QTOF analysis of bioaccessible carbohydrate metabolites in FDSW identified two phytochemical groups, alkaloids, and terpenoids. This study underscores the potential of FDSW for producing value-added bio-based products with desirable characteristics and health benefits.

AB - Valorization of fruit by-products is a crucial area of research for the development of innovative bio-based products. This study investigated the physicochemical properties and health-promoting benefits of date syrup waste, both fermented by Pichia cecembensis or Pichia kudriavzevii (FDSW), and unfermented (CDSW). Metabolomics profiles of these samples were identified post in vitro digestion. FDSW exhibited 42 volatile compounds, including 9 new ones, and contained (-)-epicatechin, tyrosol, and gallic acid. Bioaccessible fractions of FDSW demonstrated substantial α-amylase inhibition, with percentages of 40.7 % and 53.9 %, respectively. FDSW displayed superior cytotoxicity against Caco2 and MCF-7 cancer cell lines, with an average of ∼75 % and 56 %, respectively. Untargeted metabolomics analysis revealed an increase in secondary metabolites, totaling 27 metabolites. LC-QTOF analysis of bioaccessible carbohydrate metabolites in FDSW identified two phytochemical groups, alkaloids, and terpenoids. This study underscores the potential of FDSW for producing value-added bio-based products with desirable characteristics and health benefits.

KW - ACE-inhibition

KW - Antidiabetics

KW - Antioxidant

KW - Cytotoxicity

KW - Fruit waste

KW - Functional compounds

KW - Phenolic compounds

KW - UPLC-QTOF

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ER -

Unraveling the potential nutritional benefits of fermented date syrup waste: Untargeted metabolomics and carbohydrate metabolites of in vitro digested fraction

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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