TY - JOUR
T1 - Unveiling the impact of aging on BBB and Alzheimer's disease
T2 - Factors and therapeutic implications
AU - Kumar Nelson, Vinod
AU - Jha, Niraj Kumar
AU - Nuli, Mohana Vamsi
AU - Gupta, Saurabh
AU - Kanna, Sandeep
AU - Gahtani, Reem M.
AU - Hani, Umme
AU - Singh, Arun Kumar
AU - Abomughaid, Mosleh Mohammad
AU - Abomughayedh, Ali M.
AU - Almutary, Abdulmajeed G.
AU - Iqbal, Danish
AU - Al Othaim, Ayoub
AU - Begum, S. Sabarunisha
AU - Ahmad, Fuzail
AU - Mishra, Prabhu Chandra
AU - Jha, Saurabh Kumar
AU - Ojha, Shreesh
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/7
Y1 - 2024/7
N2 - Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has devastating effects on individuals, often resulting in dementia. AD is primarily defined by the presence of extracellular plaques containing insoluble β-amyloid peptide (Aβ) and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein (P-tau). In addition, individuals afflicted by these age-related illnesses experience a diminished state of health, which places significant financial strain on their loved ones. Several risk factors play a significant role in the development of AD. These factors include genetics, diet, smoking, certain diseases (such as cerebrovascular diseases, obesity, hypertension, and dyslipidemia), age, and alcohol consumption. Age-related factors are key contributors to the development of vascular-based neurodegenerative diseases such as AD. In general, the process of aging can lead to changes in the immune system's responses and can also initiate inflammation in the brain. The chronic inflammation and the inflammatory mediators found in the brain play a crucial role in the dysfunction of the blood-brain barrier (BBB). Furthermore, maintaining BBB integrity is of utmost importance in preventing a wide range of neurological disorders. Therefore, in this review, we discussed the role of age and its related factors in the breakdown of the blood-brain barrier and the development of AD. We also discussed the importance of different compounds, such as those with anti-aging properties, and other compounds that can help maintain the integrity of the blood-brain barrier in the prevention of AD. This review builds a strong correlation between age-related factors, degradation of the BBB, and its impact on AD.
AB - Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has devastating effects on individuals, often resulting in dementia. AD is primarily defined by the presence of extracellular plaques containing insoluble β-amyloid peptide (Aβ) and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein (P-tau). In addition, individuals afflicted by these age-related illnesses experience a diminished state of health, which places significant financial strain on their loved ones. Several risk factors play a significant role in the development of AD. These factors include genetics, diet, smoking, certain diseases (such as cerebrovascular diseases, obesity, hypertension, and dyslipidemia), age, and alcohol consumption. Age-related factors are key contributors to the development of vascular-based neurodegenerative diseases such as AD. In general, the process of aging can lead to changes in the immune system's responses and can also initiate inflammation in the brain. The chronic inflammation and the inflammatory mediators found in the brain play a crucial role in the dysfunction of the blood-brain barrier (BBB). Furthermore, maintaining BBB integrity is of utmost importance in preventing a wide range of neurological disorders. Therefore, in this review, we discussed the role of age and its related factors in the breakdown of the blood-brain barrier and the development of AD. We also discussed the importance of different compounds, such as those with anti-aging properties, and other compounds that can help maintain the integrity of the blood-brain barrier in the prevention of AD. This review builds a strong correlation between age-related factors, degradation of the BBB, and its impact on AD.
KW - Aging
KW - Alzheimer's disease
KW - Anti-aging compounds
KW - BBB components
KW - BBB dysfunction
KW - Inflammation
KW - Neurotherapeutics
UR - http://www.scopus.com/inward/record.url?scp=85192727138&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85192727138&partnerID=8YFLogxK
U2 - 10.1016/j.arr.2024.102224
DO - 10.1016/j.arr.2024.102224
M3 - Review article
C2 - 38346505
AN - SCOPUS:85192727138
SN - 1568-1637
VL - 98
JO - Ageing Research Reviews
JF - Ageing Research Reviews
M1 - 102224
ER -