Update in diabetic nephropathy

Enyioma N. Obineche, Abdu Adem

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)


Diabetic nephropathy has become the leading cause of end-stage kidney disease worldwide and is associated with an increased cardiovascular risk. The earliest clinical manifestation is microalbuminuria. Tight blood glucose and blood pressure control reduce the risk of microalbuminuria. Once microalbuminuria is present, the rate of progression to end stage kidney disease and cardiovascular disease can be delayed by aggressive management of blood pressure, glucose, and lipids. Inhibition of the renin-angiotensin system is important in reducing intraglomerular pressure but other classes of antihypertensive agents may also be needed to obtain adequate control of systemic blood pressure. Such measures can at least reduce by half the rate of progression of nephropathy and cardiovascular disease.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalInternational Journal of Diabetes and Metabolism
Issue number1
Publication statusPublished - 2005


  • Cardiovascular risk
  • Diabetes
  • Microalbuminuria
  • Nephropathy
  • Proteinuria

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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