TY - JOUR
T1 - Urinary megalin in association with progression factors of diabetic nephropathy
AU - Akour, A.
AU - Kasabri, V.
AU - Bulatova, N.
AU - Al-Motassem, Y.
AU - Fahmawi, H.
AU - Momani, M.
AU - Zayed, A.
AU - Alquoqa, R.
AU - AlHawari, H.
N1 - Publisher Copyright:
© 2019 Comenius University.
PY - 2019
Y1 - 2019
N2 - AIM: The aim of this study is to evaluate the association between urinary megalin, renal function, blood pressure, lipid profile, vitamin D and glycemic control in patients with type 2 diabetes mellitus (T2DM). METHODS:. This was a cross-sectional study which recruited 209 patients with T2DM. Urinary megalin was positively associated with systolic blood pressure (SBP) (r=0.218, p=0.04) but negatively with glomerular filtration rate (GFR) (r=-0.16, p=0.023). The levels of urinary albumin, triglycerides (TGs) and glycosylated hemoglobin (HbA1c) were higher in the "high-megalin" group, compared to those in "low-megalin" group. Moreover, there was a significant inverse association between vitamin D3 levels and megalin levels in urine (OR=0.281, p=0.047). CONCLUSION: Our study showed for the first time that megalin is associated with progression factors of diabetic nephropathy as well as vitamin D deficiency (Tab. 3, Fig. 1, Ref. 15). Text in PDF www.elis.sk.
AB - AIM: The aim of this study is to evaluate the association between urinary megalin, renal function, blood pressure, lipid profile, vitamin D and glycemic control in patients with type 2 diabetes mellitus (T2DM). METHODS:. This was a cross-sectional study which recruited 209 patients with T2DM. Urinary megalin was positively associated with systolic blood pressure (SBP) (r=0.218, p=0.04) but negatively with glomerular filtration rate (GFR) (r=-0.16, p=0.023). The levels of urinary albumin, triglycerides (TGs) and glycosylated hemoglobin (HbA1c) were higher in the "high-megalin" group, compared to those in "low-megalin" group. Moreover, there was a significant inverse association between vitamin D3 levels and megalin levels in urine (OR=0.281, p=0.047). CONCLUSION: Our study showed for the first time that megalin is associated with progression factors of diabetic nephropathy as well as vitamin D deficiency (Tab. 3, Fig. 1, Ref. 15). Text in PDF www.elis.sk.
KW - Biomarker
KW - Diabetic nephropathy
KW - Megalin
KW - Progression factors
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85073098786&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073098786&partnerID=8YFLogxK
U2 - 10.4149/BLL_2019_086
DO - 10.4149/BLL_2019_086
M3 - Article
C2 - 31602990
AN - SCOPUS:85073098786
SN - 0006-9248
VL - 120
SP - 532
EP - 535
JO - Bratislava Medical Journal
JF - Bratislava Medical Journal
IS - 8
ER -
