Urinary megalin in association with progression factors of diabetic nephropathy

A. Akour, V. Kasabri, N. Bulatova, Y. Al-Motassem, H. Fahmawi, M. Momani, A. Zayed, R. Alquoqa, H. AlHawari

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

AIM: The aim of this study is to evaluate the association between urinary megalin, renal function, blood pressure, lipid profile, vitamin D and glycemic control in patients with type 2 diabetes mellitus (T2DM). METHODS:. This was a cross-sectional study which recruited 209 patients with T2DM. Urinary megalin was positively associated with systolic blood pressure (SBP) (r=0.218, p=0.04) but negatively with glomerular filtration rate (GFR) (r=-0.16, p=0.023). The levels of urinary albumin, triglycerides (TGs) and glycosylated hemoglobin (HbA1c) were higher in the "high-megalin" group, compared to those in "low-megalin" group. Moreover, there was a significant inverse association between vitamin D3 levels and megalin levels in urine (OR=0.281, p=0.047). CONCLUSION: Our study showed for the first time that megalin is associated with progression factors of diabetic nephropathy as well as vitamin D deficiency (Tab. 3, Fig. 1, Ref. 15). Text in PDF www.elis.sk.

Original languageEnglish
Pages (from-to)532-535
Number of pages4
JournalBratislava Medical Journal
Volume120
Issue number8
DOIs
Publication statusPublished - 2019
Externally publishedYes

Keywords

  • Biomarker
  • Diabetic nephropathy
  • Megalin
  • Progression factors
  • Type 2 diabetes

ASJC Scopus subject areas

  • General Medicine

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