Urine metabolites and antioxidant effect after oral intake of date (Phoenix dactylifera L.) seeds-based products (powder, bread and extract) by human

Carine Platat, Serene Hillary, Francisco A. Tomas-Barberan, J. Alberto Martinez-Blazquez, Fatima Al-Meqbali, Usama Souka, Suleiman Al-Hammadi, Wissam Ibrahim

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

A cross-over study was conducted in 16 healthy adult volunteers to describe the urinary excretion of polyphenols from date seeds and investigate the antioxidant effect after consumption of different doses of date seeds powder (DSP), bread (DSB) and extract (DSE). After 12 h of fasting, one of the six treatments (0.25 g and 0.5 g/kg bodyweight DSP, 360 g of 10% and 15% DSB, 30 mg and 60 mg/kg bodyweight DSE) was provided along with breakfast, with a two weeks wash-out period between 2 consecutive treatments. Blood was drawn at baseline, 1, 2, 8 and 24 h post intake. Urine was collected at baseline, 3, 8, and 24 h post intake. An abundant release of polyphenols was detected in urine within the 0–3 h post intake, reached a peak at 8 h, then decreased with polyphenols still being detected up to 24 h post intake. The antioxidant defence system, as measured by reduced glutathione (GSH), was strengthened as soon as 1 h and up to 8 h post intake. Markers of protein and lipid oxidative damages were reduced from 1 h and up to 8 and 24 h post intake, respectively. This supports an antioxidant effect of date seeds products in humans, most probably due to their polyphenols.

Original languageEnglish
Article number2489
JournalNutrients
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2019

Keywords

  • Antioxidant
  • Date seeds
  • Human
  • Oxidative damages
  • Polyphenols
  • Proanthocyanidins
  • UPLC-ESI-QTOF(MS/MS)
  • Urine metabolites

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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