Use of novel compounds for pest control: Insecticidal and acaricidal activity of essential oil components from heartwood of Alaska Yellow Cedar

Nicholas A. Panella, Marc C. Dolan, Joseph J. Karchesy, Yeping Xiong, Javier Peralta-Cruz, Mohammad Khasawneh, John A. Montenieri, Gary O. Maupin

Research output: Contribution to journalArticlepeer-review

147 Citations (Scopus)

Abstract

Laboratory bioassays were conducted to determine the activity of 15 natural products isolated from essential oil components extracted from the heartwood of Alaska yellow cedar, Chamaecyparis nootkatensis (D. Don) Spach., against Ixodes scapularis Say nymphs, Xenopsylla cheopis (Rothchild), and Aedes oegypti (L.) adults. Four of the compounds from the essential oil have been identified as monoterpenes, five as eremophilane sesquiterpenes, five as eremophilane sesquiterpene derivatives from valencene and nootkatone, and one as a sesquiterpene outside the eremophilane parent group. Carvacrol was the only monoterpene that demonstrated biocidal activity against ticks, fleas, and mosquitoes with LC50 values after 24 h of 0.0068, 0.0059, and 0.0051% (wt:vol), respectively. Nootkatone from Alaska yellow cedar was the most effective of the eremophilane sesquiterpenes against ticks (LC50 = 0.0029%), whereas the nootkatone grapefruit extract exhibited the greatest biocidal activity against fleas (LC50 = 0.0029%). Mosquitoes were most susceptible to one of the derivatives of valencene, valencene-13-aldehyde (LC50 = 0.0024%), after 24 h. Bioassays to determine residual activity of the most effective products were conducted at 1, 2, 4, and 6 wk after initial treatment. Residual LC50 values for nootkatone did not differ significantly at 4 wk posttreatment from the observations made at the initial 24-h treatment. The ability of these natural products to kill arthropods at relatively low concentrations represents an alternative to the use of synthetic pesticides for control of disease vectors.

Original languageEnglish
Pages (from-to)352-358
Number of pages7
JournalJournal of Medical Entomology
Volume42
Issue number3
DOIs
Publication statusPublished - May 2005
Externally publishedYes

Keywords

  • Aedes aegypti
  • Ixodes scapularis
  • Natural products
  • Nootkatone
  • Xenopsylla cheopis

ASJC Scopus subject areas

  • Parasitology
  • General Veterinary
  • Insect Science
  • Infectious Diseases

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