Utilization of passive visual perception task in detecting patients with major depressive disorder for active health

Chao Chen, Xin Wang, Abdelkader Nasreddine Belkacem, Sha Sha, Xixi Zhao, Changming Wang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Depression is a common emotional and mental disease. At present, doctors' diagnosis mainly depends on the existing evaluation scales and their accumulated experience, lack of objective electrophysiological quantitative evaluation indicators. This study explores the difference in event-related potential (ERP) between patients with depression and healthy controls under the stimulation of multi-dimensional tasks, extracts the characteristic data, and uses a t-test for statistical analysis to provide an objective evaluation index for the clinical diagnosis of depression. Ninety-nine patients in the major depression group (MDD) and thirty patients in the healthy control group (HC) were used to compare the responses to positive, negative, and neutral stimulation, the results showed that there were significant differences between the left and right occipital lobes and one frontal lobe, and the frontal lobe showed lateralization; There were significant differences between the depression group and the healthy control group under multi-dimensional stimulation (P < 0.01), and the depression patients were significantly lower than the healthy patients. The results showed that emotional information was processed differently in patients with depression in the early stages of visual face processing. Therefore, EEG indices could be used as an objective index for the early detection of depression. Moreover, according to the instructions before the test, the subject is only asked to recognize visual pictures instead report emotional feelings. Stigma about psychiatric disorders could thus be reduced in this way. The explorations above facilitate designing more accurate and implicit active mental health techniques.

Original languageEnglish
Pages (from-to)226-231
Number of pages6
Publication statusPublished - Sept 2022


  • Depression
  • Facial emotion recognition
  • Neuron electrophysiology
  • SVM

ASJC Scopus subject areas

  • Molecular Biology
  • General Biochemistry,Genetics and Molecular Biology


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