Validation of the Addenbrooke's Cognitive Examination-III in Mild Cognitive Impairment in Arabic Speakers in Egypt

Tarik Qassem, Mohamed S. Khater, Tamer Emara, Doha Rasheedy, Heba M. Tawfik, Ahmed S. Mohammedin, Mohammad F. Tolba, Heba G. Saber, Dina Aly El-Gabry, Karim Abdel Aziz

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background and Aims: Mild cognitive impairment (MCI) represents an important point on the pathway to developing dementia and a target for early detection and intervention. There is a shortage of validated cognitive screening tools in Arabic to diagnose MCI. The aim of this study was to validate Addenbrooke's Cognitive Examination-III (ACE-III) (Egyptian-Arabic version) in a sample of patients with MCI, to provide cut-off scores in Egyptian-Arabic speakers. Methods: A total of 24 patients with MCI and 54 controls were included in the study and were administered the Egyptian-Arabic version of the ACE-III. Results: There was a statistically significant difference (p < 0.001) in the total ACE-III score between MCI patients (mean 75.83, standard deviation (SD) 8.1) and controls (mean 86.26, SD 6.74). There was also a statistically significant difference between MCI patients and controls in the memory, fluency, and visuospatial sub-scores of the ACE-III (p < 0.05) but not in attention and language sub-scores. Using a receiver operator characteristic curve, the optimal cut-off score for diagnosing MCI on the ACE-III total score was 81, with 75% sensitivity, 82% specificity, and 80% accuracy. Conclusions: The results of this study provide objective validation of the Egyptian-Arabic version of the ACE-III as a screening tool for MCI, with good sensitivity, specificity, and accuracy that are comparable to other translated versions of the ACE-III in MCI.

Original languageEnglish
Pages (from-to)418-422
Number of pages5
JournalDementia and Geriatric Cognitive Disorders
Issue number4
Publication statusPublished - Jan 2021


  • Addenbrooke's Cognitive Examination-III
  • Arabic version
  • Egypt
  • Mild cognitive impairment
  • Validation

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health


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