Validation of the Mini-Addenbrooke's cognitive examination in mild cognitive impairment in Arabic speakers

Tarik Qassem, Mohamed S. Khater, Tamer Emara, Doha Rasheedy, Heba M. Tawfik, Ahmed S. Mohammedin, Mohammad F. Tolba, Dina Aly El-Gabry, Karim Abdel Aziz, Heba G. Saber

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Mild cognitive impairment (MCI) represents a target for early detection and intervention in dementia, yet there is a shortage of validated screening tools in Arabic to diagnose MCI. The mini-Addenbrooke's Cognitive Examination (m-ACE) is a brief cognitive battery that is scored out of 30 and can be administered in under 5 min providing a quick screening tool for assessment of cognition. Objective: We aimed to validate the m-ACE in Arabic speakers in Egypt with MCI to provide cut-off scores. Methods: We included 24 patients with MCI and 52 controls and administered the Arabic version of the m-ACE. Results: There was a statistically significant difference (p < 0.0001) on the total m-ACE score between MCI patients (mean 18.54, SD 3.05) and controls (mean 24.54, SD 2.68). There was also a statistically significant difference between MCI patients and controls on the total score and the fluency, visuospatial, and memory recall sub-scores of the m-ACE (p < 0.05). Performance on the m-ACE significantly correlated with both the Mini-Mental State Examination (MMSE) and the Addenbrooke's Cognitive Examination-III (ACE-III). Using a receiver operator characteristic curve, the optimal cut-off score for MCI on the m-ACE total score was 21 out of 30 (87.5% sensitivity, 84.6% specificity, and 85.5% accuracy). Conclusions: We validated the Arabic m-ACE in Egyptian patients with MCI and provided objective validation of it as a screening tool for MCI, with good sensitivity, specificity, and accuracy that is comparable to other translated versions of the m-ACE in MCI.

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalDementia and Geriatric Cognitive Disorders
Volume50
Issue number2
DOIs
Publication statusPublished - Aug 1 2021

Keywords

  • Arabic
  • Egypt
  • Mild cognitive impairment
  • Mini-Addenbrooke's Cognitive Examination
  • Validation

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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