Valosin: isolation and characterization of a novel peptide from porcine intestine

Wolfgang E. Schmidt, Viktor Mutt, Mats Carlquist, Hartmut Kratzin, J. Michael Conlon, Werner Creutzfeldt

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


The isolation and primary structure of a novel gastrointestinal peptide, designated valosin, is described. The peptide was purified from porcine upper gut extracts using an HPLC and N-terminal sequence screening strategy which depends on Chromatographic and structural characteristics as isolation criterion. The amino acid sequence of this peptide consists of 25 amino acid residues: V Q Y P V E H P D K F L K F G M T P S K G V L F Y. It does not show structural homology to known protein or nucleotide sequences. According to preliminary experiments, valosin possesses biological effects on the gastrointestinal tract of the dog.

Original languageEnglish
Pages (from-to)264-268
Number of pages5
JournalFEBS Letters
Issue number2
Publication statusPublished - Oct 28 1985
Externally publishedYes


  • Gastrointestinal peptide
  • HPLC-sequence screening Primary structure
  • Isolation
  • Porcine gut extract
  • Valosin

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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