TY - JOUR
T1 - Vascular graft infection
T2 - Detection by 123I-labeled antigranulocyte antibody (anti-NCA95) scintigraphy
AU - Cordes, M.
AU - Hepp, W.
AU - Langer, R.
AU - Pannhorst, J.
AU - Hierholzer, J.
AU - Felix, R.
PY - 1991
Y1 - 1991
N2 - A total of 40 scintigraphic examinations were performed after vascular reconstructive surgery in 27 patients in whom there was a clinical suspicion of vascular graft infection. Whole-body gamma camera images were obtained at 4 and 24 h after i. v. administration of 111 MBq 123I-labeled antigranulocyte antibody Anti-NCA95. Scan results were interpreted without clinical information and were subsequently correlated with computed tomography. Prosthetic vascular graft infection was confirmed in 9 patients and excluded in 18 by surgical findings, bacteriology and/or clinical course. Scintigraphy revealed true-positive results in 18 of 40 and false-negative results in 1 of 40 examinations. True-negative results were found in 10 and 16, false-positive results in 4 and 7 examinations at 4 and 24 h p.i., resp. The sensitivity was calculated to be 94% for both early (4h) and late (24 h) images whereas the specificity was 83% and 70%, resp. In all cases the application of the murine antibody was safe and no side effects or complications were noted. Limitations of this diagnostic procedure are accumulations of granulocytes in hematomas which may be observed in the non-complicated early course following reconstructive surgery.
AB - A total of 40 scintigraphic examinations were performed after vascular reconstructive surgery in 27 patients in whom there was a clinical suspicion of vascular graft infection. Whole-body gamma camera images were obtained at 4 and 24 h after i. v. administration of 111 MBq 123I-labeled antigranulocyte antibody Anti-NCA95. Scan results were interpreted without clinical information and were subsequently correlated with computed tomography. Prosthetic vascular graft infection was confirmed in 9 patients and excluded in 18 by surgical findings, bacteriology and/or clinical course. Scintigraphy revealed true-positive results in 18 of 40 and false-negative results in 1 of 40 examinations. True-negative results were found in 10 and 16, false-positive results in 4 and 7 examinations at 4 and 24 h p.i., resp. The sensitivity was calculated to be 94% for both early (4h) and late (24 h) images whereas the specificity was 83% and 70%, resp. In all cases the application of the murine antibody was safe and no side effects or complications were noted. Limitations of this diagnostic procedure are accumulations of granulocytes in hematomas which may be observed in the non-complicated early course following reconstructive surgery.
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U2 - 10.1055/s-0038-1629571
DO - 10.1055/s-0038-1629571
M3 - Article
C2 - 1800941
AN - SCOPUS:0026003160
VL - 30
SP - 173
EP - 177
JO - Nuklearmedizin - NuclearMedicine
JF - Nuklearmedizin - NuclearMedicine
SN - 0029-5566
IS - 5
ER -