VIM-4 carbapenemase-producing Enterobacter cloacae in the United Arab Emirates

Á Sonnevend; A. Ghazawi; N. Yahfoufi; A. Al-Baloushi; R. Hashmey; M. Mathew; W. Z. Tariq; T. Pál

doi:10.1111/1469-0691.12051

VIM-4 carbapenemase-producing Enterobacter cloacae in the United Arab Emirates

Á Sonnevend, A. Ghazawi, N. Yahfoufi, A. Al-Baloushi, R. Hashmey, M. Mathew, W. Z. Tariq, T. Pál

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Screening 34 carbapenem non-susceptible Enterobacteriaceae recovered in Abu Dhabi hospitals identified an Enterobacter cloacae strain carrying bla_VIM-4, bla_CMY-4 and bla_CTX-M-15. It was isolated from the urine of an Egyptian patient repeatedly hospitalized and treated with broad-spectrum antibiotics, including carbapenems, in the United Arab Emirates. The bla_VIM-4 coding class I integron, highly similar to In416, was carried on a 175-kilobase non-conjugative incA/C type plasmid also hybridizing with the bla_CMY-4 probe. This is the first detailed report on the isolation of a Verona integron-encoded metallo-β-lactamase (VIM) -producing enteric bacterium in the Arabian Peninsula with characteristics suggestive of spreading from the Mediterranean region.

Original language	English
Pages (from-to)	E494-E496
Journal	Clinical Microbiology and Infection
Volume	18
Issue number	12
DOIs	https://doi.org/10.1111/1469-0691.12051
Publication status	Published - Dec 2012
Externally published	Yes

Keywords

Carbapenemase
Enterobacter
Middle East
Multi-drug resistance
VIM-4

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1111/1469-0691.12051

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title = "VIM-4 carbapenemase-producing Enterobacter cloacae in the United Arab Emirates",

abstract = "Screening 34 carbapenem non-susceptible Enterobacteriaceae recovered in Abu Dhabi hospitals identified an Enterobacter cloacae strain carrying blaVIM-4, blaCMY-4 and blaCTX-M-15. It was isolated from the urine of an Egyptian patient repeatedly hospitalized and treated with broad-spectrum antibiotics, including carbapenems, in the United Arab Emirates. The blaVIM-4 coding class I integron, highly similar to In416, was carried on a 175-kilobase non-conjugative incA/C type plasmid also hybridizing with the blaCMY-4 probe. This is the first detailed report on the isolation of a Verona integron-encoded metallo-β-lactamase (VIM) -producing enteric bacterium in the Arabian Peninsula with characteristics suggestive of spreading from the Mediterranean region.",

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author = "{\'A} Sonnevend and A. Ghazawi and N. Yahfoufi and A. Al-Baloushi and R. Hashmey and M. Mathew and Tariq, {W. Z.} and T. P{\'a}l",

note = "Funding Information: This work was supported by UAEU FMHS grants NP/12/13 and NP-10-11/1019. ",

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AU - Ghazawi, A.

AU - Yahfoufi, N.

AU - Al-Baloushi, A.

AU - Hashmey, R.

AU - Mathew, M.

AU - Tariq, W. Z.

AU - Pál, T.

N1 - Funding Information: This work was supported by UAEU FMHS grants NP/12/13 and NP-10-11/1019.

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AB - Screening 34 carbapenem non-susceptible Enterobacteriaceae recovered in Abu Dhabi hospitals identified an Enterobacter cloacae strain carrying blaVIM-4, blaCMY-4 and blaCTX-M-15. It was isolated from the urine of an Egyptian patient repeatedly hospitalized and treated with broad-spectrum antibiotics, including carbapenems, in the United Arab Emirates. The blaVIM-4 coding class I integron, highly similar to In416, was carried on a 175-kilobase non-conjugative incA/C type plasmid also hybridizing with the blaCMY-4 probe. This is the first detailed report on the isolation of a Verona integron-encoded metallo-β-lactamase (VIM) -producing enteric bacterium in the Arabian Peninsula with characteristics suggestive of spreading from the Mediterranean region.

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KW - Middle East

KW - Multi-drug resistance

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VIM-4 carbapenemase-producing Enterobacter cloacae in the United Arab Emirates

Abstract

Keywords

ASJC Scopus subject areas

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