Violent persons with schizophrenia and comorbid disorders: A functional magnetic resonance imaging study

C. C. Joyal; A. Putkonen; A. Mancini-Marïe; S. Hodgins; M. Kononen; L. Boulay; M. Pihlajamaki; H. Soininen; E. Stip; J. Tiihonen; H. J. Aronen

doi:10.1016/j.schres.2006.12.014

Violent persons with schizophrenia and comorbid disorders: A functional magnetic resonance imaging study

C. C. Joyal, A. Putkonen, A. Mancini-Marïe, S. Hodgins, M. Kononen, L. Boulay, M. Pihlajamaki, H. Soininen, E. Stip, J. Tiihonen, H. J. Aronen

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz + APD + SUD) would present a different pattern of prefrontal functioning than seriously violent persons with Sz only. In support with the main hypothesis, frontal basal cortices were significantly less activated in persons with Sz + APD + SUD during the execution of a go/no-go task than in persons with Sz only and non-violent persons without a mental illness. In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz + APD + SUD group than in the Sz-only group.

Original language	English
Pages (from-to)	97-102
Number of pages	6
Journal	Schizophrenia Research
Volume	91
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2006.12.014
Publication status	Published - Mar 2007
Externally published	Yes

Keywords

Antisocial personality disorder
Schizophrenia
Violence
fMRI

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2006.12.014

Cite this

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title = "Violent persons with schizophrenia and comorbid disorders: A functional magnetic resonance imaging study",

abstract = "The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz + APD + SUD) would present a different pattern of prefrontal functioning than seriously violent persons with Sz only. In support with the main hypothesis, frontal basal cortices were significantly less activated in persons with Sz + APD + SUD during the execution of a go/no-go task than in persons with Sz only and non-violent persons without a mental illness. In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz + APD + SUD group than in the Sz-only group.",

keywords = "Antisocial personality disorder, Schizophrenia, Violence, fMRI",

author = "Joyal, {C. C.} and A. Putkonen and A. Mancini-Mar{\"i}e and S. Hodgins and M. Kononen and L. Boulay and M. Pihlajamaki and H. Soininen and E. Stip and J. Tiihonen and Aronen, {H. J.}",

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T2 - A functional magnetic resonance imaging study

AU - Joyal, C. C.

AU - Putkonen, A.

AU - Mancini-Marïe, A.

AU - Hodgins, S.

AU - Kononen, M.

AU - Boulay, L.

AU - Pihlajamaki, M.

AU - Soininen, H.

AU - Stip, E.

AU - Tiihonen, J.

AU - Aronen, H. J.

PY - 2007/3

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N2 - The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz + APD + SUD) would present a different pattern of prefrontal functioning than seriously violent persons with Sz only. In support with the main hypothesis, frontal basal cortices were significantly less activated in persons with Sz + APD + SUD during the execution of a go/no-go task than in persons with Sz only and non-violent persons without a mental illness. In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz + APD + SUD group than in the Sz-only group.

AB - The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz + APD + SUD) would present a different pattern of prefrontal functioning than seriously violent persons with Sz only. In support with the main hypothesis, frontal basal cortices were significantly less activated in persons with Sz + APD + SUD during the execution of a go/no-go task than in persons with Sz only and non-violent persons without a mental illness. In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz + APD + SUD group than in the Sz-only group.

KW - Antisocial personality disorder

KW - Schizophrenia

KW - Violence

KW - fMRI

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JF - Schizophrenia Research

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Violent persons with schizophrenia and comorbid disorders: A functional magnetic resonance imaging study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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