Violent persons with schizophrenia and comorbid disorders: A functional magnetic resonance imaging study

C. C. Joyal, A. Putkonen, A. Mancini-Marïe, S. Hodgins, M. Kononen, L. Boulay, M. Pihlajamaki, H. Soininen, E. Stip, J. Tiihonen, H. J. Aronen

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz + APD + SUD) would present a different pattern of prefrontal functioning than seriously violent persons with Sz only. In support with the main hypothesis, frontal basal cortices were significantly less activated in persons with Sz + APD + SUD during the execution of a go/no-go task than in persons with Sz only and non-violent persons without a mental illness. In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz + APD + SUD group than in the Sz-only group.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalSchizophrenia Research
Volume91
Issue number1-3
DOIs
Publication statusPublished - Mar 2007
Externally publishedYes

Keywords

  • Antisocial personality disorder
  • Schizophrenia
  • Violence
  • fMRI

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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