TY - JOUR
T1 - Violent persons with schizophrenia and comorbid disorders
T2 - A functional magnetic resonance imaging study
AU - Joyal, C. C.
AU - Putkonen, A.
AU - Mancini-Marïe, A.
AU - Hodgins, S.
AU - Kononen, M.
AU - Boulay, L.
AU - Pihlajamaki, M.
AU - Soininen, H.
AU - Stip, E.
AU - Tiihonen, J.
AU - Aronen, H. J.
PY - 2007/3
Y1 - 2007/3
N2 - The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz + APD + SUD) would present a different pattern of prefrontal functioning than seriously violent persons with Sz only. In support with the main hypothesis, frontal basal cortices were significantly less activated in persons with Sz + APD + SUD during the execution of a go/no-go task than in persons with Sz only and non-violent persons without a mental illness. In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz + APD + SUD group than in the Sz-only group.
AB - The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz + APD + SUD) would present a different pattern of prefrontal functioning than seriously violent persons with Sz only. In support with the main hypothesis, frontal basal cortices were significantly less activated in persons with Sz + APD + SUD during the execution of a go/no-go task than in persons with Sz only and non-violent persons without a mental illness. In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz + APD + SUD group than in the Sz-only group.
KW - Antisocial personality disorder
KW - fMRI
KW - Schizophrenia
KW - Violence
UR - http://www.scopus.com/inward/record.url?scp=33847314118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847314118&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2006.12.014
DO - 10.1016/j.schres.2006.12.014
M3 - Article
C2 - 17291724
AN - SCOPUS:33847314118
SN - 0920-9964
VL - 91
SP - 97
EP - 102
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -
