Abstract
The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz + APD + SUD) would present a different pattern of prefrontal functioning than seriously violent persons with Sz only. In support with the main hypothesis, frontal basal cortices were significantly less activated in persons with Sz + APD + SUD during the execution of a go/no-go task than in persons with Sz only and non-violent persons without a mental illness. In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz + APD + SUD group than in the Sz-only group.
Original language | English |
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Pages (from-to) | 97-102 |
Number of pages | 6 |
Journal | Schizophrenia Research |
Volume | 91 |
Issue number | 1-3 |
DOIs | |
Publication status | Published - Mar 2007 |
Externally published | Yes |
Keywords
- Antisocial personality disorder
- Schizophrenia
- Violence
- fMRI
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry