Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders

Ali Dakroub; Suzanne A Nasser; Nour Younis; Humna Bhagani; Yusra Al-Dhaheri; Gianfranco Pintus; Assaad A. Eid; Ahmed F. El-Yazbi; Ali H. Eid

doi:10.3390/cells9112444

Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders

Ali Dakroub, Suzanne A Nasser, Nour Younis, Humna Bhagani, Yusra Al-Dhaheri, Gianfranco Pintus, Assaad A. Eid, Ahmed F. El-Yazbi, Ali H. Eid

Department of Biology

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions in nicotinamide adenine dinucleotide biosynthesis, with ubiquitous expression in skeletal muscles, liver, cardiomyocytes, and brain cells. Visfatin exists in an intracellular (iNAMPT) and extracellular (eNAMPT) form. Intracellularly, visfatin/iNAMPT plays a regulatory role in NAD+ biosynthesis and thereby affects many NAD-dependent proteins such as sirtuins, PARPs, MARTs and CD38/157. Extracellularly, visfatin is associated with many hormone-like signaling pathways and activates some intracellular signaling cascades. Importantly, eNAMPT has been associated with several metabolic disorders including obesity and type 1 and 2 diabetes. In this review, a brief overview about visfatin is presented with special emphasis on its relevance to metabolic diseases. Visfatin/NAMPT appears to be a unique molecule with clinical significance with a prospective promising diagnostic, prognostic, and therapeutic applications in many cardiovasculo-metabolic disorders.

Original language	English
Journal	Cells
Volume	9
Issue number	11
DOIs	https://doi.org/10.3390/cells9112444
Publication status	Published - Nov 9 2020

Keywords

NAD+
PARPs/MARTs
metabolic disorders
sirtuins
visfatin/NAMPT

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.3390/cells9112444

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title = "Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders",

abstract = "Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions in nicotinamide adenine dinucleotide biosynthesis, with ubiquitous expression in skeletal muscles, liver, cardiomyocytes, and brain cells. Visfatin exists in an intracellular (iNAMPT) and extracellular (eNAMPT) form. Intracellularly, visfatin/iNAMPT plays a regulatory role in NAD+ biosynthesis and thereby affects many NAD-dependent proteins such as sirtuins, PARPs, MARTs and CD38/157. Extracellularly, visfatin is associated with many hormone-like signaling pathways and activates some intracellular signaling cascades. Importantly, eNAMPT has been associated with several metabolic disorders including obesity and type 1 and 2 diabetes. In this review, a brief overview about visfatin is presented with special emphasis on its relevance to metabolic diseases. Visfatin/NAMPT appears to be a unique molecule with clinical significance with a prospective promising diagnostic, prognostic, and therapeutic applications in many cardiovasculo-metabolic disorders.",

keywords = "NAD+, PARPs/MARTs, metabolic disorders, sirtuins, visfatin/NAMPT",

author = "Ali Dakroub and {A Nasser}, Suzanne and Nour Younis and Humna Bhagani and Yusra Al-Dhaheri and Gianfranco Pintus and Eid, {Assaad A.} and El-Yazbi, {Ahmed F.} and Eid, {Ali H.}",

year = "2020",

month = nov,

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doi = "10.3390/cells9112444",

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T1 - Visfatin

T2 - A Possible Role in Cardiovasculo-Metabolic Disorders

AU - Dakroub, Ali

AU - A Nasser, Suzanne

AU - Younis, Nour

AU - Bhagani, Humna

AU - Al-Dhaheri, Yusra

AU - Pintus, Gianfranco

AU - Eid, Assaad A.

AU - El-Yazbi, Ahmed F.

AU - Eid, Ali H.

PY - 2020/11/9

Y1 - 2020/11/9

N2 - Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions in nicotinamide adenine dinucleotide biosynthesis, with ubiquitous expression in skeletal muscles, liver, cardiomyocytes, and brain cells. Visfatin exists in an intracellular (iNAMPT) and extracellular (eNAMPT) form. Intracellularly, visfatin/iNAMPT plays a regulatory role in NAD+ biosynthesis and thereby affects many NAD-dependent proteins such as sirtuins, PARPs, MARTs and CD38/157. Extracellularly, visfatin is associated with many hormone-like signaling pathways and activates some intracellular signaling cascades. Importantly, eNAMPT has been associated with several metabolic disorders including obesity and type 1 and 2 diabetes. In this review, a brief overview about visfatin is presented with special emphasis on its relevance to metabolic diseases. Visfatin/NAMPT appears to be a unique molecule with clinical significance with a prospective promising diagnostic, prognostic, and therapeutic applications in many cardiovasculo-metabolic disorders.

AB - Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions in nicotinamide adenine dinucleotide biosynthesis, with ubiquitous expression in skeletal muscles, liver, cardiomyocytes, and brain cells. Visfatin exists in an intracellular (iNAMPT) and extracellular (eNAMPT) form. Intracellularly, visfatin/iNAMPT plays a regulatory role in NAD+ biosynthesis and thereby affects many NAD-dependent proteins such as sirtuins, PARPs, MARTs and CD38/157. Extracellularly, visfatin is associated with many hormone-like signaling pathways and activates some intracellular signaling cascades. Importantly, eNAMPT has been associated with several metabolic disorders including obesity and type 1 and 2 diabetes. In this review, a brief overview about visfatin is presented with special emphasis on its relevance to metabolic diseases. Visfatin/NAMPT appears to be a unique molecule with clinical significance with a prospective promising diagnostic, prognostic, and therapeutic applications in many cardiovasculo-metabolic disorders.

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KW - PARPs/MARTs

KW - metabolic disorders

KW - sirtuins

KW - visfatin/NAMPT

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Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders

Abstract

Keywords

ASJC Scopus subject areas

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