Vliianie kofeina na khronoinotropnye vzaimootnosheniia v miokarde krysy i morskoǐ svinki.

Translated title of the contribution: Effect of caffeine on chronotropic correlations in the myocardium of the rat and guinea pig

V. G. Shevchuk, A. V. Shmygol, A. N. Verkhratski, I. N. Karvatski

Research output: Contribution to journalArticlepeer-review

Abstract

Force-frequency relations in the isolated papillary muscles of rats and guinea-pigs were compared using isometric force measurement technique. Stimulation frequency varied between 0.33 and 4 Hz. Under normal conditions the rat papillary muscle exhibits a negative force-frequency dependence which differs from ventricular preparations in many other mammals. Caffeine (10 mmol/l) introduced into the bath solution abolishes a negative force-frequency dependence in the papillary muscle of rat. During incubation of the rat ventricular preparations in the caffeine-containing solution the force-frequency relations measured on these muscles display the same behaviour as in guinea pig preparations. Caffeine has induced no changes in the force-frequency relations of guinea-pig ventricular preparations. A conclusion is made that caffeine-sensitive intracellular calcium stores participate in species-determined differences in force-frequency relations of the ventricular muscles.

Translated title of the contributionEffect of caffeine on chronotropic correlations in the myocardium of the rat and guinea pig
Original languageRussian
Pages (from-to)97-100
Number of pages4
JournalFiziologicheskii Zhurnal
Volume39
Issue number4
Publication statusPublished - Jul 1993
Externally publishedYes

ASJC Scopus subject areas

  • Physiology

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