Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects

Agneta Andersson, Siv Tengblad, Brita Karlström, Afaf Kamal-Eldin, Rikard Landberg, Samar Basu, Per Åman, Bengt Vessby

Research output: Contribution to journalArticlepeer-review

179 Citations (Scopus)

Abstract

High intakes of whole grain foods are inversely related to the incidence of coronary heart diseases and type 2 diabetes, but the mechanisms remain unclear. Our study aimed to evaluate the effects of a diet rich in whole grains compared with a diet containing the same amount of refined grains on insulin sensitivity and markers of lipid peroxidation and inflammation. In a randomized crossover study, 22 women and 8 men (BMI 28 ± 2) were given either whole-grain or refined-grain products (3 bread slices, 2 crisp bread slices, 1 portion muesli, and 1 portion pasta) to include in their habitual daily diet for two 6-wk periods. Peripheral insulin sensitivity was determined by euglycemic hyperinsulinemic clamp tests. 8-Iso-prostaglandin F (8-iso PGF), an F2-isoprostane, was measured in the urine as a marker of lipid peroxidation, and highly sensitive C-reactive protein and IL-6 were analyzed in plasma as markers of inflammation. Peripheral insulin sensitivity [mg glucose · kg body wt-1 · min -1 per unit plasma insulin (mU/L) × 100] did not improvewhen subjects consumed whole-grain products (6.8 ± 3.0 at baseline and 6.5 ± 2.7 after 6 wk) or refined products (6.4 ± 2.9 and 6.9 ± 3.2, respectively) and there were no differences between the 2 periods. Whole-grain consumption also did not affect 8-iso-PGF in urine, IL-6 and C-reactive protein in plasma, blood pressure, or serum lipid concentrations. In conclusion, substitution of whole grains (mainly based on milled wheat) for refined-grain products in the habitual daily diet of healthy moderately overweight adults for 6-wk did not affect insulin sensitivity or markers of lipid peroxidation and inflammation.

Original languageEnglish
Pages (from-to)1401-1407
Number of pages7
JournalJournal of Nutrition
Volume137
Issue number6
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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