α-synuclein and the pathogenesis of Parkinson's disease

Francis L. Martin; Sally J.M. Williamson; Katerina E. Paleologou; David Allsop; Omar M.A. El-Agnaf

doi:10.2174/0929866043407138

α-synuclein and the pathogenesis of Parkinson's disease

Francis L. Martin, Sally J.M. Williamson, Katerina E. Paleologou, David Allsop, Omar M.A. El-Agnaf

Research output: Contribution to journal › Review article › peer-review

27 Citations (Scopus)

Abstract

Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson's disease (PD) patients. Intracellular aggregation of α-synuclein (α-syn) appears to play a key role in the generation of LBs and LNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

Original language	English
Pages (from-to)	229-237
Number of pages	9
Journal	Protein and Peptide Letters
Volume	11
Issue number	3
DOIs	https://doi.org/10.2174/0929866043407138
Publication status	Published - Jun 2004
Externally published	Yes

Keywords

Comet assay
Comet tail length
DNA single-strand breaks
Environmental causation
Fe(II)
Parkinson's disease
Reactive oxygen species
α-synuclein

ASJC Scopus subject areas

Structural Biology
Biochemistry

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10.2174/0929866043407138

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title = "α-synuclein and the pathogenesis of Parkinson's disease",

abstract = "Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson's disease (PD) patients. Intracellular aggregation of α-synuclein (α-syn) appears to play a key role in the generation of LBs and LNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.",

keywords = "Comet assay, Comet tail length, DNA single-strand breaks, Environmental causation, Fe(II), Parkinson's disease, Reactive oxygen species, α-synuclein",

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T1 - α-synuclein and the pathogenesis of Parkinson's disease

AU - Martin, Francis L.

AU - Williamson, Sally J.M.

AU - Paleologou, Katerina E.

AU - Allsop, David

AU - El-Agnaf, Omar M.A.

PY - 2004/6

Y1 - 2004/6

N2 - Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson's disease (PD) patients. Intracellular aggregation of α-synuclein (α-syn) appears to play a key role in the generation of LBs and LNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

AB - Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson's disease (PD) patients. Intracellular aggregation of α-synuclein (α-syn) appears to play a key role in the generation of LBs and LNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

KW - Comet assay

KW - Comet tail length

KW - DNA single-strand breaks

KW - Environmental causation

KW - Fe(II)

KW - Parkinson's disease

KW - Reactive oxygen species

KW - α-synuclein

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JO - Protein and Peptide Letters

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α-synuclein and the pathogenesis of Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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